Estimation of multivariate probit models by exact maximum likelihood

In this paper, we develop a new numerical method to estimate a multivariate probit model. To this end, we derive a new decomposition of normal multivariate integrals that has two appealing properties. First, the decomposition may be written as the sum of normal multivariate integrals, in which the highest dimension of the integrands is reduced relative to the initial problem. Second, the domains of integration are bounded and delimited by the correlation coefficients. Application of a Gauss-Legendre quadrature rule to the exact likelihood function of lower dimension allows for a major reduction of computing time while simultaneously obtaining consistent and efficient estimates for both the slope and the scale parameters. A Monte Carlo study shows that the finite sample and asymptotic properties of our method compare extremely favorably to the maximum simulated likelihood estimator in terms of both bias and root mean squared error.Multivariate Probit Model, Simulated and Full Information Maximum Likelihood, Multivariate Normal Distribution, Simulations

Drinking locally: The implications, from a sustainability perspective, of emerging Belgian microbreweries

In similarity to other European countries and the USA, Belgium, has been facing an emergence of microbreweries in the last decade. However, given the environmental footprint and, particularly, the water footprint of beer as well as the fact that microbreweries can sometimes lag behind in energy efficiency or water usage, it is worth considering the sustainability implications of this trend. The sample of visited breweries reflects the variety, in beer volumes and geographic dispersion, of the Belgian beer sector. The data analysis is framed by a three-pillared approach to sustainability and guided by the concept of Natural Resource Accounting and Maintenance Social Sustainability, respectively, to answer the questions pertaining to the environmental performance and the local culture dimensions of microbreweries. It was observed, by comparing small- and large-scale breweries that there are differences in water consumption. Usually, higher beer volumes suggest lower water consumption levels per litre of beer produced. This can be attributed to differences in cleaning procedures, water treatment and recycling. Breweries also have varying reusing practices. The research concludes that it is important, from an early stage for breweries to embrace a holistic approach towards water consumption and waste generation in their facility. This, in turn, can contribute to breweries’ resilience and the sustainability of brewing activities, especially in light of the growing numbers of microbreweries whose aim is to satisfy the demand for a local product

Conjecture de type de Serre et formes compagnons pour GSp_4

We present a Serre-type conjecture on the modularity of four-dimensional symplectic mod p Galois representations. We assume that the Galois representation is irreducible and odd (in the symplectic sense). The modularity condition is formulated using the etale and the algebraic de Rham cohomology of Siegel modular varieties of level prime to p. We concentrate on the case when the Galois representation is ordinary at p and we give a corresponding list of Serre weights. When the representation is moreover tamely ramified at p, we conjecture that all weights of this list are modular, otherwise we describe a subset of weights on the list that should be modular. We propose a construction of de Rham cohomology classes using the dual BGG complex, which should realise some of these weights.Comment: 36 page

Thermal signatures of Little-Parks effect in the heat capacity of mesoscopic superconducting rings

We present the first measurements of thermal signatures of the Little-Parks effect using a highly sensitive nanocalorimeter. Small variations of the heat capacity $C\_p$ of 2.5 millions of non interacting micrometer-sized superconducting rings threaded by a magnetic flux $\Phi$ have been measured by attojoule calorimetry. This non-invasive method allows the measurement of thermodynamic properties -- and hence the probing of the energy levels -- of nanosystems without perturbing them electrically. It is observed that $C\_p$ is strongly influenced by the fluxoid quantization (Little-Parks effect) near the critical temperature $T\_c$. The jump of $C\_p$ at the superconducting phase transition is an oscillating function of $\Phi$ with a period $\Phi\_0=h/2e$, the magnetic flux quantum, which is in agreement with the Ginzburg-Landau theory of superconductivity.Comment: To be published in Physical Review B, Rapid Communication

Cu-Al-Ni Shape Memory Single Crystal Wires with High Transformation Temperature

CN-250X is a new material with higher performance than Nickel-Titanium Shape Memory Alloy (SMA). For space mechanisms, the main disadvantage of Nickel-Titanium Shape Memory Alloy is the limited transformation temperature. The new CN-250X Nimesis alloy is a Cu-Al-Ni single crystal wire available in large quantity because of a new industrial process. The triggering of actuators made with this Cu-Al-Ni single crystal wire can range from ambient temperature to 200 C in cycling and even to 250 C in one-shot mode. Another advantage of CN-250X is a better shape recovery (8 to 10%) than Ni-Ti (6 to 7%). Nimesis is the first company able to produce this type of material with its new special industrial process. A characterization study is presented in this work, including the two main solicitation modes for this material: tensile and torsion. Different tests measure the shape recovery of Cu-Al-Ni single crystals wires during heating from room temperature to a temperature higher than temperature of end of martensitic transformation

Marangoni-driven flower-like patterning of an evaporating drop spreading on a liquid surface

Drop motility at liquid surfaces is attracting growing interest because of its potential applications in microfluidics and artificial cell design. Here we report the unique highly-ordered pattern that sets in when a millimeter-size drop of dichloromethane spreads on an aqueous substrate under the influence of surface tension, both phases containing a surfactant. Evaporation induces a Marangoni flow that forces the development of a marked rim at the periphery of the spreading film. At some point this rim breaks up, giving rise to a ring of droplets which modifies the aqueous phase properties in such a way that the film recoils. The process repeats itself, yielding regular large-amplitude pulsations. Wrinkles form at the film surface due to an evaporative instability. During the dewetting stage, they emit equally spaced radial strings of droplets which, combined with those previously expelled from the rim, make the top view of the system resemble a flower

Monoaminergic modulation of photoreception in ascidian:evidence for a proto-hypothalamo-retinal territory

Background : The retina of craniates/vertebrates has been proposed to derive from a photoreceptor prosencephalic territory in ancestral chordates, but the evolutionary origin of the different cell types making the retina is disputed. Except for photoreceptors, the existence of homologs of retinal cells remains uncertain outside vertebrates. Methods : The expression of genes expressed in the sensory vesicle of the ascidian Ciona intestinalis including those encoding components of the monoaminergic neurotransmission systems, was analyzed by in situ hybridization or in vivo transfection of the corresponding regulatory elements driving fluorescent reporters. Modulation of photic responses by monoamines was studied by electrophysiology combined with pharmacological treatments. Results : We show that many molecular characteristics of dopamine-synthesizing cells located in the vicinity of photoreceptors in the sensory vesicle of the ascidian Ciona intestinalis are similar to those of amacrine dopamine cells of the vertebrate retina. The ascidian dopamine cells share with vertebrate amacrine cells the expression of the key-transcription factor Ptf1a, as well as that of dopamine-synthesizing enzymes. Surprisingly, the ascidian dopamine cells accumulate serotonin via a functional serotonin transporter, as some amacrine cells also do. Moreover, dopamine cells located in the vicinity of the photoreceptors modulate the light-off induced swimming behavior of ascidian larvae by acting on alpha2-like receptors, instead of dopamine receptors, supporting a role in the modulation of the photic response. These cells are located in a territory of the ascidian sensory vesicle expressing genes found both in the retina and the hypothalamus of vertebrates (six3/6, Rx, meis, pax6, visual cycle proteins). Conclusion : We propose that the dopamine cells of the ascidian larva derive from an ancestral multifunctional cell population located in the periventricular, photoreceptive field of the anterior neural tube of chordates, which also gives rise to both anterior hypothalamus and the retina in craniates/vertebrates. It also shows that the existence of multiple cell types associated with photic responses predates the formation of the vertebrate retina